Human Peptide Hormone
Active substance: Insulin Lispro (rDNA Origin)
Manufacturer: Eli Lilly
Unit: 10 mL Vial (100 IU/mL)
Humalog is a drug which comes in the form of an injectable solution in 10 mL vial.
1 mL of solution contains:
Active substance: Insulin 100 IU.
Secondary ingredients: glycerol, metacresol, zinc oxide, sodium hydrogen phosphate heptahydrate, hydrochloric acid (sodium hydroxide solution), water.
Humalog Insulin is a DNA modified analog of human insulin. A distinctive feature is a change in a combination of amino acids of the B chain of insulin.
This drug regulates glucose metabolism and has an anabolic effect. When administered to human muscle tissue, it increases the glycerol content of glycogen, fatty acids, increases protein synthesis, amino acid consumption, however, simultaneously reduces gluconeogenesis, ketogenesis, glycogenolysis, lipolysis, release of amino acids and protein catabolism.
Insulin-dependent diabetes: poor tolerance of other insulin drugs, postprandial hyperglycemia, slightly corrects other drugs; severe insulin resistance; in case of stability to antidiabetic drugs; for operations and diseases, complicating clinic diabetes.
Dose is determined individually, depending on the patient exogenous insulin sensitivity and their status. The drug is recommended to be injected before/after 15 minutes of taking meal. Usage on an individual mode. In this case, preparation temperature should be at room level.
The daily requirement can vary greatly, making in many cases 0.5-1 IU/kg. Subsequently, single daily doses and adjustments depending on the patient's metabolism and the data of multiple blood tests and urine glucose contents.
When using Humalog, is conducted as a standard injection. Injections are made in the shoulder area, buttocks, thighs or abdomen, periodically alternating between them and avoiding the use of one and the same place no more than once a month, at the same time, massaging the injection site is not recommended. When injecting it is necessary to be cautious, avoiding contact with the blood vessel.
The patient must learn the correct method of injection.
Hypoglycemia - the most common side effect due to the action of the drug. Severe hypoglycemia can cause hypoglycemic whom (loss of consciousness), in exceptional cases, the patient may die.
Allergic reactions: often in the form of local manifestations - itching at the injection site, redness or swelling at the injection site, lipodystrophy; less common allergic skin - fever, decreased blood pressure, increased sweating, angioedema, dyspnea, tachycardia.
Hypersensitivity to the drug, hypoglycemia.
Overdose of the drug may cause hypoglycemia, accompanied by lethargy, sweating, vomiting, tremor, impaired consciousness, tachycardia, headache. At the same time, hypoglycemia can occur not only in cases of drug overdose, but also can be the result of increased insulin activity caused by energy consumption or food intake. Depending on the severity of hypoglycemia conducted relevant activities.
The hypoglycemic effect of the drug increases the effects of anabolic steroids, beta-blockers, fenfluramine, tetracyclines, guanethidine, MAO inhibitors, oral hypoglycemic drugs, salicylates, sulfonamides, ACE inhibitors, Octreotides.
It is not recommended to mix Humalog with animal insulin preparations, but it can be administered under the supervision of a doctor with a long-acting human insulin.
10 mL vial with 100 IU per mL.
Store in refrigerator, do not freeze, at a temperature of +2° to 8°C. Shelf life - 2 years.
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