Epitalon 50 mg

Peptide Hubs Epitalon 50 mg

Peptide Hubs presents Epitalon 50 mg, a high-dose lyophilized powder formulation of the renowned synthetic tetrapeptide (Ala-Glu-Asp-Gly). This concentrated 50 mg vial offers researchers extended supply and flexible dosing options for in-depth investigations into cellular aging, epigenetic regulation, and circadian biology. As the high-potency counterpart to the standard 25 mg version, this product provides double the active substance per vial, making it ideal for longer research cycles, multi-subject studies, or protocols exploring varied dosing regimens. For athletes, biohackers, and serious longevity researchers, the Epitalon 50 mg vial represents an efficient and powerful tool for studying the frontiers of telomerase activation, pineal gland restoration, and systemic anti-aging interventions.

Epitalon 50 mg Composition

Each sterile 2 mL vial contains 50 mg of synthetic Epitalon, composed of the precise tetrapeptide sequence: L-Alanyl-L-Glutamyl-L-Asparagyl-L-Glycine. This high-concentration formulation ensures researchers have ample material for repeated dosing within a single vial. The product is supplied as a pure, white lyophilized powder without fillers, binders, or preservatives. Its simplicity—just four amino acids—contributes to its stability and research reliability. Reconstitution with bacteriostatic water is required prior to use in investigative protocols.

Bodybuilding and Athletic Research Benefits

The 50 mg concentration of Epitalon enables more expansive research into its indirect but critical benefits for athletic performance and resilience. Key investigational areas include: enhanced cellular repair and reduced systemic inflammation through potential telomere maintenance and senescent cell clearance; improved recovery and sleep architecture via normalization of melatonin production and circadian rhythms, critical for nocturnal anabolic hormone release; increased resistance to oxidative and training-induced stress at the cellular level; and potential support for joint and connective tissue health through systemic anti-aging mechanisms. For athletes focused on longevity in sport and mitigating the cumulative damage of intense training, high-dose Epitalon provides a robust model for studying foundational cellular health.

Therapeutic and Research Indication

Epitalon is a premier research peptide in the field of biogerontology. Its primary indications in research are telomerase activation, epigenetic modulation of aging-related genes, and restoration of pineal gland function. The high 50 mg dose allows for exploration of dose-response relationships and longer-term studies. Foundational research, such as that referenced by the National Institutes of Health (NIH), has explored peptides like epithalamin (the natural precursor) for extending healthspan and modulating age-related pathologies.

Mechanism of Action: High-Dose Epigenetic Signaling

At the 50 mg dose level, Epitalon's mechanisms remain the same but allow researchers to explore the saturation and duration of its effects. It functions as an epigenetic modulator, binding to specific receptors (potentially involving the pineal gland and chromatin) to alter gene expression. It upregulates telomerase activity in cells capable of producing the enzyme, promoting telomere elongation. It also stimulates the synthesis of melatonin in a youthful pattern, resetting circadian oscillators. The higher dose may influence the intensity or persistence of these signaling cascades, making it a subject for research on optimal dosing for maximum biological effect.

Dosage for Research (Men) - High-Dose Considerations

The 50 mg vial offers flexibility. The standard research protocol remains 5-10 mg administered subcutaneously once daily for 10-20 days. With this vial, a researcher can conduct a full 10-day course at 5 mg/day, a 10-day course at 10 mg/day, or even explore higher doses (e.g., 20 mg/day for shorter periods) in specific experimental designs. The key principle from prior research is the short, intensive course rather than chronic low dosing. Intranasal administration for direct CNS delivery is also a viable research route with this concentration.

Dosage for Research (Women) - High-Dose Considerations

Research dosing for female subjects typically follows the same 5-10 mg daily range, utilizing the 50 mg vial for convenience and extended supply. There is no pharmacological reason for gender-based dose adjustment for its core mechanisms. The high-dose vial is particularly useful for research involving multiple female subjects or for longitudinal studies where supply consistency is important.

Active Life and Half-Life

Epitalon's pharmacokinetics are characterized by a short plasma half-life due to its small peptide size. However, its biological effects are mediated through lasting changes in gene expression and enzyme activity (like telomerase), which can persist for weeks or months after a course of administration. The 50 mg dose does not alter the half-life but may affect the magnitude or duration of the downstream epigenetic and hormonal changes, which is a key variable for research.

Epitalon 50 mg Side Effects

Extensive clinical and preclinical research on Epitalon has demonstrated an exemplary safety profile across a wide dose range. No significant adverse effects have been reported at standard or even higher research doses. Its action is regulatory and restorative, not pharmacologically disruptive. The most commonly noted subjective effect in studies is vivid dreaming during the administration period, attributed to its pineal gland activity. The 50 mg dose, when used responsibly within established protocols, maintains this favorable safety and tolerability profile.

Contraindications and Precautionary Measures

The same precautions apply to the 50 mg strength. It is contraindicated in research involving subjects with active or suspected malignancies due to the theoretical concern of telomerase activation in occult cancer cells. While evidence suggests it normalizes rather than promotes pathology, this is a standard ethical precaution. Research should not involve pregnant or nursing subjects. Epitalon is strictly for controlled laboratory research and not for human consumption or anti-aging therapy.

Overdosage in Research

The risk of acute toxicity is minimal. Epitalon works through receptor-mediated signaling pathways that have natural limits. Extremely high, non-physiological doses are unlikely to cause harm but would be inefficient and wasteful. The 50 mg vial is designed to support standard research dosing with convenience, not to encourage excessive use. Responsible research design always prioritizes established, biologically active dose ranges.

Epitalon 50 mg Stack/Cycle for Research

The 50 mg vial facilitates more complex and prolonged stacking research. It can be effectively combined with other longevity and performance peptides for synergistic studies:

• GHK-Cu for a comprehensive "Master Anti-Aging" research stack, pairing epigenetic regulation (Epitalon) with systemic repair and collagen stimulation (GHK-Cu).
• NAD+ 500 mg to investigate the synergy between the genetic longevity pathway (Epitalon/telomeres) and the metabolic longevity pathway (NAD+/sirtuins) in cellular health models.
• MOTS-c for research on mitochondrial peptide signaling (MOTS-c) combined with nuclear/genomic aging regulation (Epitalon).
• Thymosin Alpha-1 to study combined immune system rejuvenation (Thymosin) and cellular senescence delay (Epitalon) in models of aging or intense stress.
• Glow Blend for exploring multifaceted approaches to skin health, collagen, and systemic vitality, comparing a targeted peptide (Epitalon) to a multi-ingredient blend.

Package Presentation

The product is supplied as one sterile glass vial containing 50 mg of Epitalon as a white lyophilized powder. The vial is sealed with a bromobutyl rubber stopper and an aluminum crimp cap to ensure sterility and long-term stability. The packaging is discreet and designed to protect the peptide during transit.

Storage

For maximum stability of this high-value peptide, long-term storage at or below -20°C (-4°F) is strongly recommended. For short-term use during an active research course, refrigeration at 2-8°C (36-46°F) is acceptable. After reconstitution with bacteriostatic water, the solution must be refrigerated and used within 7-10 days to ensure potency, as with all peptides.

Epitalon 50 mg Referrers

The scientific rationale for Epitalon is supported by decades of research from the Russian school of bioregulation and gerontology, primarily led by Professor Vladimir Khavinson. Key references include studies demonstrating its effects on lifespan extension in animals, telomerase activity in cell cultures, and clinical improvements in elderly humans. Researchers are encouraged to delve into this specialized literature to understand the historical context, dosing rationales, and observed outcomes that make Epitalon a unique compound in longevity research.