Melanotan 2 10 mg

Peptide Hubs Melanotan 2

Melanotan 2 by Peptide Hubs is a synthetic analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH), presented as a 10 mg lyophilized powder in a sterile 2 mL vial. Developed through advanced peptide synthesis technology, this compound has garnered significant research interest for its potent melanocortin receptor agonist activity. Manufactured under stringent quality control protocols and independently verified through third-party laboratory analysis, Peptide Hubs Melanotan 2 offers researchers a reliable and precisely dosed tool for scientific investigation into melanogenesis and related physiological pathways.

Melanotan 2 Chemical Composition

Each vial contains 10 mg of high-purity Melanotan II (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂), a cyclic heptapeptide analog of α-MSH. The molecular structure features:

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1024.19 g/mol
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• Purity: >99% confirmed by HPLC analysis
• Form: Lyophilized white powder

The cyclic structure enhances metabolic stability compared to linear peptides, while specific amino acid substitutions increase receptor affinity and prolong biological activity in research models.

Research Applications and Investigative Benefits

In controlled research settings, Melanotan 2 presents several significant areas of scientific interest:

• Melanogenesis Research: As a potent non-selective melanocortin receptor agonist, MT-2 stimulates melanin production in melanocytes, making it valuable for studies on skin pigmentation mechanisms and UV photoprotection.
• Metabolic Studies: Research indicates melanocortin receptors influence appetite regulation and energy homeostasis, positioning MT-2 as a tool for investigating metabolic pathways.
• Libido and Sexual Function Research: Studies referenced in the Journal of Sexual Medicine suggest melanocortin agonists may affect sexual arousal pathways in animal models.
• Anti-Inflammatory Properties: Emerging research explores potential anti-inflammatory effects mediated through melanocortin receptor activation in various tissue models.

Therapeutic Research Context

While this product is for research use only, previous scientific literature provides context for its investigative applications. Melanotan 2 was originally developed as a potential photoprotective agent for individuals with sun sensitivity. According to research published in the Pigment Cell & Melanoma Research Journal, synthetic melanocortin analogs like MT-2 demonstrate potent pigment-inducing properties in both in vitro and in vivo models. This research foundation makes Melanotan 2 a valuable compound for studying melanocyte biology, skin response mechanisms, and related physiological processes.

Research Dosage Parameters

Important: The following information is derived from published research and should only guide experimental design in appropriate research models. Always consult institutional protocols.

• Standard Research Range: Studies typically use doses of 0.1-0.5 mg/kg in animal models, administered via subcutaneous injection.
• Reconstitution Protocol: Add 2 mL of bacteriostatic water to yield a concentration of 5 mg/mL (5000 mcg/mL). For precise dosing, further dilution may be required based on model size.
• Loading Phase: Some protocols initiate with 0.5 mg/kg daily for 5-7 days to achieve steady-state receptor activation.
• Maintenance Phase: Following loading, research often continues with 0.25 mg/kg 2-3 times weekly to maintain effects.

Active Research Life and Pharmacokinetics

Melanotan 2 demonstrates favorable pharmacokinetic properties for research applications:

• Half-Life: Approximately 2-3 hours in research models, significantly longer than natural α-MSH
• Onset of Observable Effects: Initial melanogenesis typically observed within 24-48 hours in responsive models
• Peak Concentration: Reached within 30-60 minutes post-administration
• Duration of Action: Biological effects persist beyond the compound's plasma half-life due to sustained receptor activation
• Elimination: Primarily renal clearance with some hepatic metabolism

Potential Research Observations

Researchers should monitor for expected biological responses consistent with melanocortin receptor activation:

• Pigmentation Changes: Progressive darkening of skin/fur in pigmented models
• Appetite Modulation: Potential reduction in food intake in some research models
• Physiological Responses: Possible transient increases in blood pressure, heart rate, or yawning/stretching behaviors
• Local Reactions: Minor erythema or discomfort at injection sites in sensitive models
• Systemic Effects: Nausea or flushing reported in some research protocols during initial administration

Research Contraindications & Precautionary Measures

This product is for laboratory research use only. Researchers should:

• Not administer to humans or animals for cosmetic or therapeutic purposes
• Avoid use in research models with pre-existing cardiovascular conditions
• Exercise caution in studies involving models with dark pigmented lesions or melanoma history
• Use appropriate personal protective equipment during handling
• Conduct research in certified laboratory facilities with proper ventilation
• Store securely with restricted access to prevent unauthorized use
• Dispose of materials according to institutional biohazard protocols

Overdose in Research Context

Administration significantly above established research parameters may produce exaggerated physiological responses including severe nausea, pronounced cardiovascular effects, or extreme pigmentation changes that could compromise animal welfare and study validity. Researchers should adhere to institutional Animal Care and Use Committee (IACUC) guidelines and establish appropriate dose-escalation protocols. Emergency procedures should be in place for managing acute adverse reactions in research models.

Melanotan 2 Research Stack/Cycle Integration

For comprehensive research approaches, Melanotan 2 may be studied alongside other Peptide Hubs products in controlled experimental designs. Researchers might investigate combinations such as:

• PT-141 (Bremelanotide): To compare and contrast effects of different melanocortin receptor agonists on sexual behavior and pigmentation pathways in research models.
• GHRP-2: For studies exploring potential synergistic effects on growth hormone release and metabolic parameters.
• Tesamorelin: In research examining combined effects on body composition and metabolic parameters in animal models.

These research combinations should only be conducted by qualified investigators following appropriate experimental designs, ethical guidelines, and institutional approvals.

Package Presentation

Each research unit arrives in discreet pharmaceutical packaging containing:

• One sterile glass vial with bromobutyl rubber stopper containing 10 mg lyophilized Melanotan II
• Tamper-evident seal ensuring product integrity
• Lot number and expiration date (24 months from manufacture) for tracking
• Accompanying certificate of analysis from independent laboratory
• Product insert with handling and storage information

Storage & Stability Protocols

For optimal preservation of research integrity:

• Unreconstituted: Store at 2-8°C (36-46°F) in original packaging. Protect from light. Stable for 24 months from manufacture when properly stored.
• Reconstituted: Use immediately in research applications. If necessary, store at 2-8°C (36-46°F) for no more than 7-10 days while maintaining sterility.
• Handling: Allow vials to reach room temperature before reconstitution to prevent condensation. Use aseptic technique throughout.
• Freezing: Do not freeze reconstituted solution. Lyophilized powder should not be stored frozen.

Melanotan 2 Research Referrers

The scientific investigation of melanocortin analogs continues to evolve across multiple research domains. Melanotan 2's development stemmed from efforts to create synthetic peptides with enhanced stability and receptor affinity compared to natural α-MSH. Its broad melanocortin receptor activation profile (MC1R, MC3R, MC4R, MC5R) makes it a versatile tool for studying diverse physiological systems including pigmentation, inflammation, metabolism, and sexual function. Peptide Hubs maintains rigorous quality assurance through independent third-party verification, ensuring researchers receive materials of precisely documented composition and purity for their investigative work. The April 22, 2025 laboratory analysis confirming 10.45 mg content (104.5% of labeled amount) exemplifies this commitment to accuracy and transparency in research materials.

Third-Party Laboratory Verification

April 22, 2025

View Result

10.45 mg / 10 mg

The independent laboratory analysis conducted on April 22, 2025, confirms the Melanotan 2 vial contains 10.45 mg of active peptide content against the labeled 10 mg, representing a 104.5% purity rating. This verification exceeds quality standards and ensures researchers receive accurately dosed materials for their investigations.